N,N-Diisopropylethylamine (DIPEA)
CAS 7087-68-5
Hünig’s Base · C₈H₁₉N · MW 129.24
Product Overview
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a highly hindered tertiary amine widely used as a non-nucleophilic base in organic synthesis. With its excellent solubility in organic solvents and minimal nucleophilicity, DIPEA is the preferred base for peptide coupling, alkylation reactions, enolboration, and palladium-catalyzed alkoxycarbonylation. Our product achieves 99.97% purity (GC) with water content below 0.01%, exceeding standard pharmaceutical-grade specifications.
Technical Specifications
| CAS Number | 7087-68-5 |
|---|---|
| Molecular Formula | C₈H₁₉N |
| Molecular Weight | 129.24 g/mol |
| Appearance | Colorless clear liquid |
| Purity (GC) | ≥99.70% (Actual: 99.97%) |
| Diisopropylamine | ≤0.05% (Not Detected) |
| Any Single Impurity | ≤0.10% |
| Water Content (KF) | ≤0.05% (Actual: 0.01%) |
| Color (APHA) | ≤25 |
| Boiling Point | 127 °C |
| Density | 0.742 g/mL at 25 °C |
Batch QC Data (Lot 26-05-08)
Applications
🧬 Peptide Synthesis
Preferred non-nucleophilic base for solid-phase and solution-phase peptide coupling. Compatible with HBTU, HATU, and carbodiimide activation methods. The extreme steric hindrance ensures no racemization of sensitive amino acids.
⚗️ Alkylation & Acylation
Ideal for N-alkylation, O-alkylation, and acylation reactions where strong inorganic bases cause side reactions. Provides clean product profiles with minimal elimination byproducts.
🔬 Pd-Catalyzed Reactions
Base of choice for palladium-catalyzed alkoxycarbonylation, Heck coupling, and Sonogashira reactions. Non-nucleophilic nature prevents catalyst poisoning and ensures high turnover numbers.
💊 Pharmaceutical Intermediates
Key reagent in the synthesis of antiviral agents (HIV protease inhibitors), oncology APIs, and CNS-targeted drug candidates. Used where trace amine contamination is unacceptable.